Plasminostreptin, a Protein Proteinase Inhibitor Produced by Streptomyces antifibrinolyticus*
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چکیده
A novel protein proteinase inhibitor, plasminostreptin, which is capable of inhibiting the activities of plasmin (EC 3.4.21.7). trypsin (EC 3.4.21.4). and microbial alkaline proteinases such as subtilisin (EC 3.4.21.141, was isolated from the culture fluid of Streptomyces antifibrinolyticus IF
منابع مشابه
Plasminostreptin, a protein proteinase inhibitor produced by Streptomyces antifibrinolyticus. II. Determination of the reactive site for proteinases.
Chemical modification of the amino groups of plasminostreptin with 2,4,6-trinitrobenzene sulfonic acid or O-methylisourea completely abolished its inhibitory activities against trypsin (EC 3.4.21.4) and plasmin (EC 3.4.21.7). This indicated that plasminostreptin requires at least 1 lysine residue for its trypsin and plasmin inhibitory activities. Incubation of plasminostreptin with a small amou...
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تاریخ انتشار 2002